What concentration of 2-Hexanediol is effective?

Typical effective concentrations of 2-Hexanediol are Typically 0.5–2% in leave-on products, up to 5% in rinse-off formulations. Used at lower concentrations when acting as a preservative booster..

What skin types is 2-Hexanediol suitable for?

2-Hexanediol is suitable for all skin types, oily, acne-prone, sensitive, combination, dry.

The Skin Formulary

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Researched by Helena DeMaria-Williams

Formula IngredientHumectant, Solvent

2-Hexanediol

Q: Can 2-Hexanediol cause skin irritation?

2-Hexanediol has a low irritation risk. Well-tolerated at cosmetic concentrations (typically 0.5–2%). No EU CosIng Annex II or III restrictions apply. At higher concentrations it may cause mild transient irritation, but this is uncommon in standard formulations. Sensitisation potential is considered very low.

Q: Is 2-Hexanediol safe to use during pregnancy?

2-Hexanediol is rated "caution" for pregnancy use. No specific reproductive or developmental toxicity concerns have been identified in cosmetic use databases. However, dedicated pregnancy safety studies are limited. At typical cosmetic concentrations (0.5–2%), systemic absorption is very low and risk is considered minimal. Consult a healthcare provider if concerned.

Q: Does 2-Hexanediol increase sun sensitivity?

2-Hexanediol has a no sun sensitivity risk. 1,2-Hexanediol does not increase photosensitivity. No sun protection precautions are needed based on its presence in a formulation.

INCI: 1,2-Hexanediol

1,2-Hexanediol is a short-chain diol (two hydroxyl groups on a six-carbon chain) used in cosmetics as a humectant, solvent, and antimicrobial booster. It helps retain moisture in the skin and contributes a soft, pleasant skin feel. It is also widely used to enhance the efficacy of traditional preservatives, allowing formulators to reduce their concentration.

What does this do in a formula?

moisturisation, skin conditioning, solvent for active ingredients, antimicrobial preservative boosting, improves skin feel, pigment dispersion in makeup

Is 2-Hexanediol safe? Key considerations

Can 2-Hexanediol cause irritation?

Low Risk

Well-tolerated at cosmetic concentrations (typically 0.5–2%). No EU CosIng Annex II or III restrictions apply. At higher concentrations it may cause mild transient irritation, but this is uncommon in standard formulations. Sensitisation potential is considered very low.

Does 2-Hexanediol increase sun sensitivity?

No Risk

1,2-Hexanediol does not increase photosensitivity. No sun protection precautions are needed based on its presence in a formulation.

Is 2-Hexanediol safe during pregnancy?

Caution

No specific reproductive or developmental toxicity concerns have been identified in cosmetic use databases. However, dedicated pregnancy safety studies are limited. At typical cosmetic concentrations (0.5–2%), systemic absorption is very low and risk is considered minimal. Consult a healthcare provider if concerned.

How does 2-Hexanediol work?

Which products contain 2-Hexanediol?

Shop products that contain 2-Hexanediol

2-Hexanediol

What does this do in a formula?

Is 2-Hexanediol safe? Key considerations

Can 2-Hexanediol cause irritation?

Does 2-Hexanediol increase sun sensitivity?

Is 2-Hexanediol safe during pregnancy?

How does 2-Hexanediol work?

Which products contain 2-Hexanediol?

Starter Retinol Serum

Oat Cleansing Balm

Dewy Sunscreen SPF 30

Retinol Eye Cream

PHA Toner

Cetaphil Gentle Clear Pimple Patches

Glycolic Acid 7% Exfoliating Toner

Caffeine Solution 5% + EGCG Eye Serum

Multi-Peptide Lash and Brow Serum

AHA 30% + BHA 2% Peeling Solution

Ascorbyl Glucoside Solution 12%

Marine Hyaluronics

Amino Acids + B5

Lactic Acid 5% + HA

Lactic Acid 10% + HA

Mandelic Acid 10% + HA

Hyaluronic Acid 2% + B5 (Original Formulation)

Rice Lipids + Ectoin Microemulsion