Researched by Helena DeMaria-Williams
Formula IngredientPeptideINCI: Acetyl Hexapeptide-1
Acetyl hexapeptide-1 (trade name: Melitane) is a synthetic peptide composed of alanine, arginine, histidine, leucine, phenylalanine, and tryptophan, acetylated with acetic acid. Unlike most cosmetic peptides which target wrinkles, this peptide promotes melanin production by interacting with the MC1R (melanocortin 1 receptor) on skin cells. It enhances both natural and artificial tanning, provides UV protection by supporting melanin's natural defence mechanism, and helps protect against UV-induced DNA damage and free radical damage.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, fair skin wanting enhanced tanning, UV-exposed skin
melanin stimulation, enhanced tanning, UV protection support, anti-UV DNA damage, free radical protection, reduced UV-induced redness
Acetyl hexapeptide-1 is a synthetic peptide used at very low concentrations with no known irritation concerns. Peptides are generally non-irritating. No EU CosIng Annex II or III restrictions apply.
Acetyl hexapeptide-1 does not increase photosensitivity. On the contrary, it supports the skin's natural UV defence by promoting melanin production. It should not be considered a substitute for SPF.
MANUAL REVIEW: Limited pregnancy-specific safety data available for this synthetic peptide. While topical peptides are generally considered low risk due to minimal systemic absorption, no specific pregnancy safety studies were identified. Consult a healthcare provider.
Acetyl hexapeptide-1 (trade name: Melitane) is a synthetic peptide composed of alanine, arginine, histidine, leucine, phenylalanine, and tryptophan, acetylated with acetic acid. Unlike most cosmetic peptides which target wrinkles, this peptide promotes melanin production by interacting with the MC1R (melanocortin 1 receptor) on skin cells. It enhances both natural and artificial tanning, provides UV protection by supporting melanin's natural defence mechanism, and helps protect against UV-induced DNA damage and free radical damage.
Individuals with history of melanoma or skin cancer (due to melanin-stimulating mechanism — consult dermatologist) should review the considerations above before use.
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