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Researched by Helena DeMaria-Williams

Formula IngredientPeptide

Acetyl Hexapeptide-1

INCI: Acetyl Hexapeptide-1

Acetyl hexapeptide-1 (trade name: Melitane) is a synthetic peptide composed of alanine, arginine, histidine, leucine, phenylalanine, and tryptophan, acetylated with acetic acid. Unlike most cosmetic peptides which target wrinkles, this peptide promotes melanin production by interacting with the MC1R (melanocortin 1 receptor) on skin cells. It enhances both natural and artificial tanning, provides UV protection by supporting melanin's natural defence mechanism, and helps protect against UV-induced DNA damage and free radical damage.

Category

Peptide

Irritation Risk

Low

Skin Types

all skin types, fair skin wanting enhanced tanning, UV-exposed skin

What does this do in a formula?

melanin stimulation, enhanced tanning, UV protection support, anti-UV DNA damage, free radical protection, reduced UV-induced redness

Is Acetyl Hexapeptide-1 safe? Key considerations

Can Acetyl Hexapeptide-1 cause irritation?

Low Risk

Acetyl hexapeptide-1 is a synthetic peptide used at very low concentrations with no known irritation concerns. Peptides are generally non-irritating. No EU CosIng Annex II or III restrictions apply.

Does Acetyl Hexapeptide-1 increase sun sensitivity?

No Risk

Acetyl hexapeptide-1 does not increase photosensitivity. On the contrary, it supports the skin's natural UV defence by promoting melanin production. It should not be considered a substitute for SPF.

Is Acetyl Hexapeptide-1 safe during pregnancy?

Caution

MANUAL REVIEW: Limited pregnancy-specific safety data available for this synthetic peptide. While topical peptides are generally considered low risk due to minimal systemic absorption, no specific pregnancy safety studies were identified. Consult a healthcare provider.

How does Acetyl Hexapeptide-1 work?

Acetyl hexapeptide-1 (trade name: Melitane) is a synthetic peptide composed of alanine, arginine, histidine, leucine, phenylalanine, and tryptophan, acetylated with acetic acid. Unlike most cosmetic peptides which target wrinkles, this peptide promotes melanin production by interacting with the MC1R (melanocortin 1 receptor) on skin cells. It enhances both natural and artificial tanning, provides UV protection by supporting melanin's natural defence mechanism, and helps protect against UV-induced DNA damage and free radical damage.

Individuals with history of melanoma or skin cancer (due to melanin-stimulating mechanism — consult dermatologist) should review the considerations above before use.

Which products contain Acetyl Hexapeptide-1?

Shop products that contain Acetyl Hexapeptide-1