Researched by Helena DeMaria-Williams
Formula IngredientPeptideAcetyl Hexapeptide-37
INCI: Acetyl Hexapeptide-37
Acetyl Hexapeptide-37 (trade name Diffuporine™) is a synthetic signal peptide developed by Lipotec S.A. using combinatorial screening technology. Its amino acid sequence is Ac-L-Ser-L-Pro-L-Ala-Gly-Gly-L-Pro-NH2. It works primarily by upregulating the expression of Aquaporin-3 (AQP3), a water-channel protein in the skin, increasing its production by up to twice, which enhances the transport of water from deeper epidermal layers to the stratum corneum and improves overall skin hydration.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, dry, dehydrated, ageing, sensitive, oily, acne-prone
What does this do in a formula?
enhanced skin hydration, improved barrier function, reduced transepidermal water loss, collagen type I synthesis stimulation, keratinocyte proliferation, improved skin firmness and elasticity, reduced fine lines and wrinkles, anti-ageing
Is Acetyl Hexapeptide-37 safe? Key considerations
Can Acetyl Hexapeptide-37 cause irritation?
Low RiskAdverse reactions to acetyl hexapeptide-37 are uncommon. It is a synthetic peptide composed of naturally occurring amino acids and is generally well tolerated by all skin types, including sensitive skin. No EU CosIng Annex II or III restrictions apply. Patch testing is recommended for individuals with known peptide sensitivities.
Does Acetyl Hexapeptide-37 increase sun sensitivity?
No RiskAcetyl hexapeptide-37 does not increase photosensitivity. No special sun protection measures are required based on its presence in a formulation.
Is Acetyl Hexapeptide-37 safe during pregnancy?
CautionLimited safety data exists for topical use of acetyl hexapeptide-37 during pregnancy and breastfeeding. No known risks have been identified from available sources (Motherfigure), and the ingredient is composed of amino acids naturally found in the body. However, due to the absence of dedicated reproductive safety studies, consulting a healthcare provider before use is advisable.
How does Acetyl Hexapeptide-37 work?
Acetyl Hexapeptide-37 (trade name Diffuporine™) is a synthetic signal peptide developed by Lipotec S.A. using combinatorial screening technology. Its amino acid sequence is Ac-L-Ser-L-Pro-L-Ala-Gly-Gly-L-Pro-NH2. It works primarily by upregulating the expression of Aquaporin-3 (AQP3), a water-channel protein in the skin, increasing its production by up to twice, which enhances the transport of water from deeper epidermal layers to the stratum corneum and improves overall skin hydration.
Individuals with known peptide allergy (rare) should review the considerations above before use.
Which products contain Acetyl Hexapeptide-37?
Shop products that contain Acetyl Hexapeptide-37
