Researched by Helena DeMaria-Williams
Formula IngredientPeptideAcetylarginyltryptophyl Diphenylglycine
INCI: Acetylarginyltryptophyl Diphenylglycine
Acetylarginyltryptophyl diphenylglycine (trade name Relistase) is a synthetic tetrapeptide formed from acetic acid, arginine, tryptophan, and phenylglycine. It works by inhibiting elastase, an enzyme that degrades collagen and elastin in the skin, and by stimulating type I collagen synthesis, making it an anti-ageing cell-communicating ingredient. It also has a calming effect on reactive skin by moderating the release of inflammatory mediators.
Category
Peptide
Irritation Risk
Low
Skin Types
mature skin, anti-ageing, sensitive skin, reactive skin, acne-prone, all skin types
What does this do in a formula?
elastase inhibition, collagen stimulation, improved skin firmness, improved skin elasticity, soothing reactive skin, reducing redness, barrier support
Is Acetylarginyltryptophyl Diphenylglycine safe? Key considerations
Can Acetylarginyltryptophyl Diphenylglycine cause irritation?
Low RiskConsidered safe and well-tolerated for topical cosmetic use with low hazard ratings. Patch testing is advisable for highly sensitive skin types as minor irritation is possible. No EU CosIng Annex II or III restrictions identified for this ingredient.
Does Acetylarginyltryptophyl Diphenylglycine increase sun sensitivity?
No RiskAcetylarginyltryptophyl diphenylglycine is a peptide and does not increase photosensitivity. No special sun protection measures are required based on the presence of this ingredient.
Is Acetylarginyltryptophyl Diphenylglycine safe during pregnancy?
MANUAL REVIEW: No pregnancy safety data found across any consulted source (INCIDecoder, EWG, Skincarelab). General peptide caution applies — consult a healthcare provider.No specific pregnancy safety data is available for this ingredient from EWG, INCIDecoder, or Skincarelab. It is a synthetic peptide with no known systemic absorption concerns at cosmetic concentrations, but the absence of data means a precautionary approach is advised. Consult a healthcare provider before use during pregnancy.
How does Acetylarginyltryptophyl Diphenylglycine work?
Acetylarginyltryptophyl diphenylglycine (trade name Relistase) is a synthetic tetrapeptide formed from acetic acid, arginine, tryptophan, and phenylglycine. It works by inhibiting elastase, an enzyme that degrades collagen and elastin in the skin, and by stimulating type I collagen synthesis, making it an anti-ageing cell-communicating ingredient. It also has a calming effect on reactive skin by moderating the release of inflammatory mediators.
Individuals with known peptide allergy should review the considerations above before use.
Which products contain Acetylarginyltryptophyl Diphenylglycine?
Shop products that contain Acetylarginyltryptophyl Diphenylglycine
