Researched by Helena DeMaria-Williams
Formula IngredientSkin Conditioning AgentDarutoside
INCI: Darutoside
Darutoside is a plant-derived diterpene glycoside extracted primarily from Siegesbeckia orientalis (St. Paul's wort), a shrub used in traditional Asian medicine. It functions as a skin conditioning agent that stimulates collagen and elastin production, promotes wound healing by facilitating fibroblast migration, and exerts anti-inflammatory effects by inhibiting NF-κB signalling pathways. Its structural similarity to triterpenes found in Centella asiatica accounts for its tissue-regenerating and matrix-rebuilding properties.
Category
Skin Conditioning Agent
Irritation Risk
Low
Skin Types
all skin types, dry, oily, combination, sensitive, mature, acne-prone
What does this do in a formula?
collagen stimulation, elastin production, anti-inflammatory, wound healing, skin firming, hydration, reduces fine lines and wrinkles, reduces stretch mark appearance, soothes redness and irritation
Is Darutoside safe? Key considerations
Can Darutoside cause irritation?
Low RiskDarutoside has a very low irritation potential. It is a small, water-soluble molecule used at low concentrations in formulations. No EU CosIng Annex II or III restrictions apply. Patch testing is recommended for highly reactive or allergy-prone individuals, but it is generally well tolerated across all skin types.
Does Darutoside increase sun sensitivity?
No RiskDarutoside has no known photosensitising mechanism. No increased sun sensitivity has been reported with topical use. Standard daily SPF habits are sufficient.
Is Darutoside safe during pregnancy?
AvoidAnimal studies (PubMed PMID 2618680) have identified abortifacient activity in darutoside derived from Siegesbeckia glabrescens at dosages of 20–40 mg/kg in experimental rats, with the compound classified as a nonsteroidal abortifacient agent. While topical cosmetic concentrations are far lower than those tested, the precautionary principle warrants avoidance during pregnancy. Consult a healthcare provider before use.
How does Darutoside work?
Darutoside is a plant-derived diterpene glycoside extracted primarily from Siegesbeckia orientalis (St. Paul's wort), a shrub used in traditional Asian medicine. It functions as a skin conditioning agent that stimulates collagen and elastin production, promotes wound healing by facilitating fibroblast migration, and exerts anti-inflammatory effects by inhibiting NF-κB signalling pathways. Its structural similarity to triterpenes found in Centella asiatica accounts for its tissue-regenerating and matrix-rebuilding properties.
Individuals with pregnancy should review the considerations above before use.
Which products contain Darutoside?
Shop products that contain Darutoside
