Researched by Helena DeMaria-Williams
Formula IngredientPeptideDipeptide Diaminobutyroyl Benzylamide Diacetate
INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate
Dipeptide diaminobutyroyl benzylamide diacetate (trade name SYN-AKE) is a synthetic tripeptide designed to mimic the action of Waglerin-1, a peptide found in temple viper venom. It works by acting as an antagonist at muscular nicotinic acetylcholine receptors, temporarily inhibiting nerve-to-muscle signalling and reducing facial muscle contractions. The result is a smoothing of expression-related lines and wrinkles without injection.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, mature skin, anti-ageing concerns, expression lines, combination, oily, acne-prone
What does this do in a formula?
reduces expression lines and wrinkles, smooths fine lines, anti-ageing, muscle-relaxing peptide effect
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe? Key considerations
Can Dipeptide Diaminobutyroyl Benzylamide Diacetate cause irritation?
Low RiskRated 1/10 (low hazard) by EWG Skin Deep. Generally well tolerated at cosmetic concentrations of 1–4%. Those with very sensitive skin may experience mild redness, itching, or a burning sensation; patch testing is recommended. No EU CosIng Annex II or III restrictions apply to this ingredient.
Does Dipeptide Diaminobutyroyl Benzylamide Diacetate increase sun sensitivity?
No RiskDipeptide diaminobutyroyl benzylamide diacetate is not an exfoliant or retinoid and does not increase photosensitivity. No additional sun protection is required based solely on its presence in a formulation.
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe during pregnancy?
CautionNo dedicated reproductive safety studies exist for this ingredient. Its mechanism (acetylcholine receptor antagonism) is pharmacologically active, and limited systemic absorption data is available. As a precaution, pregnant individuals should consult a healthcare provider before use. Avoid high-concentration professional treatments. (Source: general principles from PMC3114665; no specific MotherToBaby or EWG developmental flag found.)
How does Dipeptide Diaminobutyroyl Benzylamide Diacetate work?
Dipeptide diaminobutyroyl benzylamide diacetate (trade name SYN-AKE) is a synthetic tripeptide designed to mimic the action of Waglerin-1, a peptide found in temple viper venom. It works by acting as an antagonist at muscular nicotinic acetylcholine receptors, temporarily inhibiting nerve-to-muscle signalling and reducing facial muscle contractions. The result is a smoothing of expression-related lines and wrinkles without injection.
Individuals with known peptide sensitivity, neuromuscular conditions (consult physician), pregnancy (consult physician) should review the considerations above before use.
Which products contain Dipeptide Diaminobutyroyl Benzylamide Diacetate?
Shop products that contain Dipeptide Diaminobutyroyl Benzylamide Diacetate
