Researched by Helena DeMaria-Williams
Formula IngredientAntioxidant, FlavonoidINCI: Glucosylrutin
Glucosylrutin (also known as alpha-glucosylrutin or AGR) is a water-soluble, glycosylated derivative of rutin — a bioflavonoid found naturally in plants. The glucose molecule attached to rutin dramatically improves its skin bioavailability and stability compared to rutin alone, allowing it to penetrate the epidermis effectively. It works by scavenging free radicals, neutralising reactive oxygen species (ROS) generated by UV radiation, and protecting against UVA-induced photooxidative damage in skin cells.
Category
Antioxidant, Flavonoid
Irritation Risk
Low
Skin Types
all skin types, sensitive, oily, acne-prone, hyperpigmentation, photoaged skin, UV-exposed skin
antioxidant protection, UV-induced oxidative stress reduction, photoaging prevention, anti-inflammatory, skin brightening, dark spot reduction
Glucosylrutin is well tolerated at cosmetic concentrations. No EU CosIng Annex II or III restrictions apply. Multiple clinical studies involving topical application have not reported significant irritation. The bioflavonoid class is generally considered non-irritating. Sensitive skin types are unlikely to experience adverse reactions.
Glucosylrutin does not increase photosensitivity — in fact, it is used specifically to protect against UV-induced oxidative stress. Clinical evidence (Rippke et al., 2001) demonstrates that topical pre-treatment reduces UVA-induced photooxidation. No SPF precautions are required based on its presence in a formulation.
No specific pregnancy safety data was found for topical glucosylrutin. Rutin and flavonoids are generally regarded as low risk at cosmetic concentrations due to minimal systemic absorption. No reproductive or developmental red flags were identified in available safety literature. Classified as MANUAL REVIEW due to absence of dedicated pregnancy safety studies.
Glucosylrutin (also known as alpha-glucosylrutin or AGR) is a water-soluble, glycosylated derivative of rutin — a bioflavonoid found naturally in plants. The glucose molecule attached to rutin dramatically improves its skin bioavailability and stability compared to rutin alone, allowing it to penetrate the epidermis effectively. It works by scavenging free radicals, neutralising reactive oxygen species (ROS) generated by UV radiation, and protecting against UVA-induced photooxidative damage in skin cells.
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