Researched by Helena DeMaria-Williams
Formula IngredientAmino AcidHistidine
INCI: Histidine
Histidine is a semi-essential amino acid that occurs naturally in the skin as part of the Natural Moisturising Factor (NMF). It functions as a humectant and skin-conditioning agent, drawing moisture into the stratum corneum. In the skin, histidine is a precursor to urocanic acid, which contributes to UV protection and barrier function, and it plays a role in regulating immune defence and inflammatory processes.
Category
Amino Acid
Irritation Risk
Low
Skin Types
all skin types, dry, sensitive, dehydrated, acne-prone, mature skin
What does this do in a formula?
moisturisation, skin barrier support, skin conditioning, antioxidant support, anti-inflammatory, potential antimicrobial protection
Is Histidine safe? Key considerations
Can Histidine cause irritation?
Low RiskHistidine is a skin-identical amino acid with an excellent safety profile. It is non-irritating at cosmetic concentrations. No EU CosIng Annex II or III restrictions apply. The CIR (Cosmetic Ingredient Review) panel has assessed amino acids including histidine as safe for cosmetic use.
Does Histidine increase sun sensitivity?
No RiskHistidine does not increase photosensitivity. Its metabolite urocanic acid is naturally produced in skin and has some UV-absorbing properties, but histidine itself does not sensitise skin to sunlight.
Is Histidine safe during pregnancy?
SafeHistidine is a naturally occurring amino acid found in the body and in food. It is widely considered safe during pregnancy. No reproductive or developmental concerns have been identified for topical cosmetic use.
How does Histidine work?
Histidine is a semi-essential amino acid that occurs naturally in the skin as part of the Natural Moisturising Factor (NMF). It functions as a humectant and skin-conditioning agent, drawing moisture into the stratum corneum. In the skin, histidine is a precursor to urocanic acid, which contributes to UV protection and barrier function, and it plays a role in regulating immune defence and inflammatory processes.
Which products contain Histidine?
Shop products that contain Histidine
Glycolic Acid 7% Exfoliating Toner
Multi-Peptide + Copper Peptides 1% Serum
Natural Moisturizing Factors + HA
Multi-Peptide + HA Serum
Marine Hyaluronics
