Researched by Helena DeMaria-Williams
Formula IngredientHumectantHydrolyzed Sodium Hyaluronate
INCI: Hydrolyzed Sodium Hyaluronate
Hydrolyzed sodium hyaluronate (also called miniHA) is a low-molecular-weight form of sodium hyaluronate, produced by enzymatic or chemical hydrolysis to reduce the molecular weight to approximately 10 kDa — far smaller than the 500–2000 kDa of standard sodium hyaluronate. This reduced size allows it to penetrate more deeply into the upper layers of the epidermis compared to standard hyaluronic acid. It functions as a powerful humectant, drawing and retaining moisture in the skin, and also exhibits antioxidant properties and enhanced after-sun repair activity.
Category
Humectant
Irritation Risk
Low
Skin Types
all skin types, dry, dehydrated, mature, oily, acne-prone, combination, sensitive
What does this do in a formula?
deep penetration moisturisation, humectancy, antioxidant activity, enhanced after-sun repair, plumping fine lines, synergistic hydration when combined with high-molecular-weight HA
Is Hydrolyzed Sodium Hyaluronate safe? Key considerations
Can Hydrolyzed Sodium Hyaluronate cause irritation?
Low RiskGenerally well tolerated. However, fragments below 50 kDa have been shown in vitro (reconstituted human epidermis models) to act as pro-inflammatory signalling agents, potentially activating immune responses. Evidence in live skin is limited and this effect has not been consistently reproduced in clinical settings. Not restricted under EU CosIng Annex II or III. Patch testing recommended for very sensitive or barrier-compromised skin.
Does Hydrolyzed Sodium Hyaluronate increase sun sensitivity?
No RiskHydrolyzed sodium hyaluronate does not increase photosensitivity. No UV-sensitising properties are attributed to hyaluronate-family ingredients. Standard daily SPF is always recommended but is not specifically necessitated by this ingredient.
Is Hydrolyzed Sodium Hyaluronate safe during pregnancy?
SafeHydrolyzed sodium hyaluronate is a derivative of hyaluronic acid, a naturally occurring substance in the body. Topical application at cosmetic concentrations is considered low risk during pregnancy. No reproductive or developmental toxicity concerns are noted in available safety databases. Consult a healthcare provider if in doubt.
How does Hydrolyzed Sodium Hyaluronate work?
Hydrolyzed sodium hyaluronate (also called miniHA) is a low-molecular-weight form of sodium hyaluronate, produced by enzymatic or chemical hydrolysis to reduce the molecular weight to approximately 10 kDa — far smaller than the 500–2000 kDa of standard sodium hyaluronate. This reduced size allows it to penetrate more deeply into the upper layers of the epidermis compared to standard hyaluronic acid. It functions as a powerful humectant, drawing and retaining moisture in the skin, and also exhibits antioxidant properties and enhanced after-sun repair activity.
Individuals with MANUAL REVIEW: No firm contraindications established; those with severely compromised skin barriers may wish to patch test given the in vitro pro-inflammatory data for LMW HA fragments should review the considerations above before use.
Which products contain Hydrolyzed Sodium Hyaluronate?
Shop products that contain Hydrolyzed Sodium Hyaluronate
