The Skin Formulary
IngredientsBrandsJournalShop
Browse Products

By The Skin Formulary Team

Formula IngredientHumectant, Skin Conditioning

Hydroxyethyl Urea

INCI: Hydroxyethyl Urea

Hydroxyethyl urea is a urea derivative (INCI: Hydroxyethyl Urea; CAS 1320-51-0; EC 215-304-0) formed by the reaction of urea with ethylene oxide, resulting in a molecule that combines urea's powerful water-binding ability with improved skin feel. It functions as a strong humectant and skin conditioner, drawing moisture into the stratum corneum and improving skin elasticity and hydration. Unlike its parent molecule urea, it delivers moisturising performance without the sticky or tacky feel sometimes associated with glycerin, making it particularly valued in lightweight, elegant formulations.

Category

Humectant, Skin Conditioning

Irritation Risk

Low

Skin Types

all skin types, dry, dehydrated, combination, oily, acne-prone, sensitive, mature

What does this do in a formula?

deep humectant hydration, improved skin elasticity, smoothing rough texture, enhanced skin feel compared to glycerin, non-sticky moisture retention, hair conditioning

Important Considerations

Irritation Risk

Low Risk

Hydroxyethyl urea is well tolerated at typical cosmetic concentrations (2–10%). As a urea derivative it shares the mild irritancy profile of its parent compound. No EU CosIng Annex II or III restrictions apply. Individuals with known hypersensitivity to urea-based compounds should patch test, but true sensitisation is rare. Not a known irritant or allergen in standard formulations.

Sun Sensitivity Risk

No Risk

Hydroxyethyl urea does not increase photosensitivity. It has no UV-absorbing structure and does not affect the skin's response to UV radiation. No SPF precautions are required based solely on the presence of this ingredient.

Pregnancy Concerns

Safe

Hydroxyethyl urea is considered safe for topical use during pregnancy at standard cosmetic concentrations. It is a urea derivative with no known reproductive or developmental toxicity. No concerns are flagged in available cosmetic safety databases. Systemic absorption from topical leave-on products at typical use levels is negligible.

About This Ingredient

Hydroxyethyl urea is a urea derivative (INCI: Hydroxyethyl Urea; CAS 1320-51-0; EC 215-304-0) formed by the reaction of urea with ethylene oxide, resulting in a molecule that combines urea's powerful water-binding ability with improved skin feel. It functions as a strong humectant and skin conditioner, drawing moisture into the stratum corneum and improving skin elasticity and hydration. Unlike its parent molecule urea, it delivers moisturising performance without the sticky or tacky feel sometimes associated with glycerin, making it particularly valued in lightweight, elegant formulations.

Individuals with known hypersensitivity to urea or urea derivatives should review the considerations above before use.