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Researched by Helena DeMaria-Williams

Formula IngredientSoothing Agent

Madecassoside

INCI: Madecassoside

Madecassoside is a pentacyclic triterpene saponin derived from Centella Asiatica (gotu kola). It is one of the four key active compounds in Centella (alongside asiaticoside, madecassic acid, and asiatic acid). It has well-documented wound healing, anti-inflammatory, and antioxidant properties, and may also stimulate collagen synthesis and inhibit UV-induced melanin production.

Category

Soothing Agent

Irritation Risk

Low

Skin Types

all skin types, sensitive skin, irritated skin, redness-prone skin, acne-prone skin, ageing skin, hyperpigmentation

What does this do in a formula?

wound healing, skin soothing, anti-inflammatory, antioxidant, collagen stimulation, anti-hyperpigmentation, redness reduction, itch relief

Is Madecassoside safe? Key considerations

Can Madecassoside cause irritation?

Low Risk

Very well tolerated. Studies at 0.05-0.2% showed excellent tolerability. Centella-derived actives are widely used for calming sensitive and irritated skin.

Does Madecassoside increase sun sensitivity?

No Risk

Does not increase photosensitivity. May help reduce UV-induced melanin synthesis.

Is Madecassoside safe during pregnancy?

Safe

Centella Asiatica derivatives have a long history of safe topical use. No documented reproductive concerns at cosmetic concentrations.

How does Madecassoside work?

Madecassoside is a pentacyclic triterpene saponin derived from Centella Asiatica (gotu kola). It is one of the four key active compounds in Centella (alongside asiaticoside, madecassic acid, and asiatic acid). It has well-documented wound healing, anti-inflammatory, and antioxidant properties, and may also stimulate collagen synthesis and inhibit UV-induced melanin production.

Individuals with known allergy to Centella Asiatica or Apiaceae family plants should review the considerations above before use.