Researched by Helena DeMaria-Williams
Formula IngredientPeptideMyristoyl Nonapeptide-3
INCI: Myristoyl Nonapeptide-3
Myristoyl Nonapeptide-3 is a synthetic nine-amino-acid peptide conjugated with myristic acid, designed to mimic the effects of retinol without the associated irritation. Gene array screening shows it upregulates 16 genes also affected by retinoic acid, and ex-vivo testing demonstrated that a 10% cream induced a 43% increase in collagen-1 synthesis, comparable to 0.1% retinoic acid. It increases cell turnover and promotes collagen production while being significantly better tolerated than retinoids.
Category
Peptide
Irritation Risk
Low
Skin Types
sensitive skin, retinoid-intolerant skin, anti-ageing concerns, all skin types
What does this do in a formula?
collagen stimulation, retinol-like effects, anti-ageing, cell turnover, reduced irritation vs retinoids
Is Myristoyl Nonapeptide-3 safe? Key considerations
Can Myristoyl Nonapeptide-3 cause irritation?
Low RiskSignificantly lower irritation potential than retinol or retinoic acid. No EU CosIng Annex II or III restrictions apply. Specifically designed as a gentler alternative to retinoids for sensitive skin.
Does Myristoyl Nonapeptide-3 increase sun sensitivity?
Caution RiskMANUAL REVIEW: As this peptide mimics retinol activity and increases cell turnover, some degree of photosensitivity may be possible, though this has not been specifically studied. Using SPF as a precaution is advisable.
Is Myristoyl Nonapeptide-3 safe during pregnancy?
CautionMANUAL REVIEW: While this is a peptide (not a retinoid), it mimics retinol gene expression. No pregnancy safety studies are available. Consult a healthcare provider, especially given its retinol-mimicking mechanism.
How does Myristoyl Nonapeptide-3 work?
Myristoyl Nonapeptide-3 is a synthetic nine-amino-acid peptide conjugated with myristic acid, designed to mimic the effects of retinol without the associated irritation. Gene array screening shows it upregulates 16 genes also affected by retinoic acid, and ex-vivo testing demonstrated that a 10% cream induced a 43% increase in collagen-1 synthesis, comparable to 0.1% retinoic acid. It increases cell turnover and promotes collagen production while being significantly better tolerated than retinoids.
Which products contain Myristoyl Nonapeptide-3?
Shop products that contain Myristoyl Nonapeptide-3
