Researched by Helena DeMaria-Williams
Formula IngredientPeptideOligopeptide-1
INCI: Oligopeptide-1
Oligopeptide-1 is the INCI name for GHK (glycyl-histidyl-lysine), a naturally occurring tripeptide composed of glycine, histidine, and lysine. It was first isolated from human plasma albumin and is found endogenously in the skin, where concentrations decline with age. It works through two primary mechanisms: binding copper(II) ions to support enzymatic activity and copper transport, and regulating gene expression — with studies showing it modulates approximately 31% of human genes, upregulating pathways involved in collagen synthesis, tissue remodelling, and antioxidant defence.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, ageing skin, dull skin, hyperpigmentation, sensitive skin, post-procedure skin
What does this do in a formula?
collagen stimulation, anti-ageing, skin firming, wound healing, barrier repair, antioxidant activity, hyperpigmentation reduction, skin smoothing
Is Oligopeptide-1 safe? Key considerations
Can Oligopeptide-1 cause irritation?
Low RiskDecades of cosmetic use have not produced documented irritation reports. No EU CosIng Annex II or III restrictions apply. Well tolerated in formulations targeting sensitive skin, including eye area products. No known irritation threshold.
Does Oligopeptide-1 increase sun sensitivity?
No RiskOligopeptide-1 does not increase photosensitivity. Clinical research notes it may help reduce UV-induced photodamage and hyperpigmentation. No additional sun protection measures are required based on its presence in a formulation.
Is Oligopeptide-1 safe during pregnancy?
CautionMANUAL REVIEW: No pregnancy-specific safety data identified in available sources (CosIng, PubChem, PMC literature). As a bioactive peptide capable of influencing gene expression, topical use is likely low risk, but the absence of data warrants consultation with a healthcare provider. Conservative cosmetic guidance is to use with caution.
How does Oligopeptide-1 work?
Oligopeptide-1 is the INCI name for GHK (glycyl-histidyl-lysine), a naturally occurring tripeptide composed of glycine, histidine, and lysine. It was first isolated from human plasma albumin and is found endogenously in the skin, where concentrations decline with age. It works through two primary mechanisms: binding copper(II) ions to support enzymatic activity and copper transport, and regulating gene expression — with studies showing it modulates approximately 31% of human genes, upregulating pathways involved in collagen synthesis, tissue remodelling, and antioxidant defence.
Which products contain Oligopeptide-1?
Shop products that contain Oligopeptide-1
