What concentration of Palmitoyl Isoleucine is effective?

Typical effective concentrations of Palmitoyl Isoleucine are Typically used at 0.5-3% in serums, creams, and anti-ageing formulations.

What skin types is Palmitoyl Isoleucine suitable for?

Palmitoyl Isoleucine is suitable for all skin types, normal, dry, oily, combination, sensitive, acne-prone, ageing skin.

The Skin Formulary

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Researched by Helena DeMaria-Williams

Formula IngredientSkin Protectant, Lipopeptide

Palmitoyl Isoleucine

Q: Can Palmitoyl Isoleucine cause skin irritation?

Palmitoyl Isoleucine has a low irritation risk. Palmitoyl isoleucine is generally well tolerated across all skin types. Rare cases of mild redness or stinging may occur in very sensitive individuals. No EU Annex II or III restrictions apply.

Q: Is Palmitoyl Isoleucine safe to use during pregnancy?

Palmitoyl Isoleucine is rated "safe" for pregnancy use. No specific safety warnings exist for pregnancy. As a topical lipopeptide with no known systemic absorption concerns, it is generally considered safe. Consult a healthcare provider if concerned.

Q: Does Palmitoyl Isoleucine increase sun sensitivity?

Palmitoyl Isoleucine has a no sun sensitivity risk. Palmitoyl isoleucine does not increase photosensitivity.

INCI: Palmitoyl Isoleucine

Palmitoyl Isoleucine is a lipopeptide (lipoamino acid) formed by combining palmitic acid with the essential amino acid isoleucine. This structure allows it to integrate into the skin's lipid matrix, reinforcing the barrier between skin cells. It is used in anti-ageing, firming, and barrier-repair formulations for its skin-protecting and conditioning properties.

What does this do in a formula?

skin barrier reinforcement, reduced transepidermal water loss, improved skin elasticity, sebum regulation, skin conditioning, anti-ageing support

Is Palmitoyl Isoleucine safe? Key considerations

Can Palmitoyl Isoleucine cause irritation?

Low Risk

Palmitoyl isoleucine is generally well tolerated across all skin types. Rare cases of mild redness or stinging may occur in very sensitive individuals. No EU Annex II or III restrictions apply.

Does Palmitoyl Isoleucine increase sun sensitivity?

No Risk

Palmitoyl isoleucine does not increase photosensitivity.

Is Palmitoyl Isoleucine safe during pregnancy?

Safe

No specific safety warnings exist for pregnancy. As a topical lipopeptide with no known systemic absorption concerns, it is generally considered safe. Consult a healthcare provider if concerned.

How does Palmitoyl Isoleucine work?

Individuals with known allergy to fatty acid derivatives should review the considerations above before use.

Which products contain Palmitoyl Isoleucine?

Shop products that contain Palmitoyl Isoleucine

Volufiline 92% + Pal-Isoleucine 1%

Volufiline™: 92%Palmitoyl isoleucine: 1%

£19.50View →