Researched by Helena DeMaria-Williams
Formula IngredientPeptidePalmitoyl Pentapeptide-4
INCI: Palmitoyl Pentapeptide-4
Palmitoyl pentapeptide-4, sold under the trade name Matrixyl, is a cell-communicating peptide composed of five amino acids (lysine–threonine–threonine–lysine–serine, or KTTKS) derived from type I collagen, with palmitic acid attached to improve skin penetration and oil solubility. It works by signalling fibroblasts to produce collagen, elastin and hyaluronic acid, mimicking the body's natural wound-healing response. Clinical studies show it can reduce the appearance of fine lines and wrinkles at very low concentrations (as low as 0.0003%).
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, sensitive skin, mature skin, anti-ageing concerns, those who cannot tolerate retinol
What does this do in a formula?
reduces fine lines and wrinkles, stimulates collagen synthesis, improves skin elasticity, smooths skin texture, anti-ageing
Is Palmitoyl Pentapeptide-4 safe? Key considerations
Can Palmitoyl Pentapeptide-4 cause irritation?
Low RiskWell tolerated by most skin types including sensitive skin. No significant EU Annex restrictions apply. Clinical evidence indicates better tolerability compared to retinol. Rarely reported to cause irritation.
Does Palmitoyl Pentapeptide-4 increase sun sensitivity?
No RiskPalmitoyl pentapeptide-4 does not increase photosensitivity. No SPF precautions are required specifically for this ingredient, though broad-spectrum SPF is always recommended as part of an anti-ageing routine.
Is Palmitoyl Pentapeptide-4 safe during pregnancy?
SafePeptides are not flagged as a concern during pregnancy. No restrictions identified by EWG or MotherToBaby. Unlike retinoids, palmitoyl pentapeptide-4 is considered a safe anti-ageing alternative for pregnant individuals.
How does Palmitoyl Pentapeptide-4 work?
Palmitoyl pentapeptide-4, sold under the trade name Matrixyl, is a cell-communicating peptide composed of five amino acids (lysine–threonine–threonine–lysine–serine, or KTTKS) derived from type I collagen, with palmitic acid attached to improve skin penetration and oil solubility. It works by signalling fibroblasts to produce collagen, elastin and hyaluronic acid, mimicking the body's natural wound-healing response. Clinical studies show it can reduce the appearance of fine lines and wrinkles at very low concentrations (as low as 0.0003%).
Individuals with known hypersensitivity to peptide formulations (rare) should review the considerations above before use.
Which products contain Palmitoyl Pentapeptide-4?
Shop products that contain Palmitoyl Pentapeptide-4
