Researched by Helena DeMaria-Williams
Formula IngredientPeptidePalmitoyl Tetrapeptide-7
INCI: Palmitoyl Tetrapeptide-7
Palmitoyl tetrapeptide-7 is a synthetic cell-communicating peptide composed of four amino acids (glycine-glutamine-proline-arginine) bonded to palmitic acid, which enhances its oil solubility and penetration into the skin. It works by reducing the production of interleukin-6 (IL-6), an inflammatory signalling molecule, thereby slowing collagen degradation and supporting a firmer, more youthful-looking complexion. It is the anti-inflammatory counterpart to palmitoyl tripeptide-1 within the well-known Matrixyl 3000 complex.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, mature skin, anti-ageing concerns, sensitive skin, oily, dry, combination
What does this do in a formula?
anti-inflammatory, collagen-protecting, firming, anti-ageing, reduces signs of photoageing
Is Palmitoyl Tetrapeptide-7 safe? Key considerations
Can Palmitoyl Tetrapeptide-7 cause irritation?
Low RiskPalmitoyl tetrapeptide-7 is well tolerated at typical cosmetic concentrations. As a synthetic peptide, it does not have the same irritation potential as chemical exfoliants or retinoids. No EU CosIng Annex II or III restrictions apply. Sensitive skin types are unlikely to react adversely.
Does Palmitoyl Tetrapeptide-7 increase sun sensitivity?
No RiskPalmitoyl tetrapeptide-7 does not increase photosensitivity. It has no UV-sensitising properties. No additional sun protection is required specifically because of this ingredient, though broad-spectrum SPF is always recommended as part of an anti-ageing routine.
Is Palmitoyl Tetrapeptide-7 safe during pregnancy?
MANUAL REVIEW: no reproductive toxicology data found in available sources; considered low risk by general peptide safety profile but not formally studiedNo specific pregnancy safety data for palmitoyl tetrapeptide-7 was found in EWG Skin Deep or MotherToBaby databases. As a large synthetic peptide with low systemic absorption, topical use is generally considered low risk; however, no formal classification exists. Consult a healthcare provider if in doubt.
How does Palmitoyl Tetrapeptide-7 work?
Palmitoyl tetrapeptide-7 is a synthetic cell-communicating peptide composed of four amino acids (glycine-glutamine-proline-arginine) bonded to palmitic acid, which enhances its oil solubility and penetration into the skin. It works by reducing the production of interleukin-6 (IL-6), an inflammatory signalling molecule, thereby slowing collagen degradation and supporting a firmer, more youthful-looking complexion. It is the anti-inflammatory counterpart to palmitoyl tripeptide-1 within the well-known Matrixyl 3000 complex.
Which products contain Palmitoyl Tetrapeptide-7?
Shop products that contain Palmitoyl Tetrapeptide-7
Caffeine Eye Cream
Hyaluronic Acid Serum
Hyaluronic Acid Serum
Supersize Hyaluronic Acid Serum
Collagen Peptide Serum
Retinol Serum
Multi-Peptide + Copper Peptides 1% Serum
Matrixyl 10% + HA
