Researched by Helena DeMaria-Williams
Formula IngredientPeptidePalmitoyl Tripeptide-38
INCI: Palmitoyl Tripeptide-38
Palmitoyl tripeptide-38 (commercially known as Matrixyl synthe'6) is a synthetic lipopeptide with the sequence Pal-Lys-Met(O2)-Lys, created by bonding palmitic acid to a three-amino-acid chain. It acts as a matrikine-mimetic signal peptide, communicating with skin cells to stimulate the production of six key extracellular matrix components: collagen types I, III, and IV, fibronectin, hyaluronic acid, and laminin-5. By supporting both the epidermis and dermis, it helps firm skin, reduce wrinkle depth, and improve texture and tone.
Category
Peptide
Irritation Risk
Low
Skin Types
mature skin, anti-ageing concerns, dry skin, normal skin, combination skin
What does this do in a formula?
anti-ageing, wrinkle reduction, skin firming, collagen stimulation, hyaluronic acid synthesis, skin tone homogeneity, smoothing texture, hydration support
Is Palmitoyl Tripeptide-38 safe? Key considerations
Can Palmitoyl Tripeptide-38 cause irritation?
Low RiskWell tolerated by most skin types at typical use concentrations. No EU CosIng Annex II or III restrictions apply. As with any peptide, individuals with very sensitive skin may experience mild reactions; patch testing is recommended. EWG Skin Deep rates its overall hazard as low.
Does Palmitoyl Tripeptide-38 increase sun sensitivity?
No RiskPalmitoyl tripeptide-38 does not increase photosensitivity. It is not an exfoliating acid or retinoid and poses no known UV-related risk. Standard daily SPF is always recommended as general skincare practice.
Is Palmitoyl Tripeptide-38 safe during pregnancy?
CautionEWG Skin Deep reports a low rating for developmental and reproductive toxicity. However, the Cosmetic Ingredient Review (CIR) found no reproductive or developmental toxicity data in published literature. Due to limited research, pregnant and breastfeeding individuals should consult their healthcare provider before use, even though no known risk has been identified.
How does Palmitoyl Tripeptide-38 work?
Palmitoyl tripeptide-38 (commercially known as Matrixyl synthe'6) is a synthetic lipopeptide with the sequence Pal-Lys-Met(O2)-Lys, created by bonding palmitic acid to a three-amino-acid chain. It acts as a matrikine-mimetic signal peptide, communicating with skin cells to stimulate the production of six key extracellular matrix components: collagen types I, III, and IV, fibronectin, hyaluronic acid, and laminin-5. By supporting both the epidermis and dermis, it helps firm skin, reduce wrinkle depth, and improve texture and tone.
Individuals with known peptide sensitivity; blemish-prone skin should patch test due to slight comedogenic potential should review the considerations above before use.
Which products contain Palmitoyl Tripeptide-38?
Shop products that contain Palmitoyl Tripeptide-38
Tripeptide Plumping Lip Balm
Multi-Peptide + Copper Peptides 1% Serum
Matrixyl 10% + HA
Multi-Peptide Eye Serum
