Researched by Helena DeMaria-Williams
Formula IngredientPeptidePentapeptide-18
INCI: Pentapeptide-18
Pentapeptide-18, sold under the trade name Leuphasyl, is a synthetic signal peptide composed of five amino acids (tyrosine, alanine, glycine, phenylalanine, and leucine). It works by mimicking the action of enkephalins — natural neurotransmitter-inhibiting peptides — to reduce the intensity of muscle micro-contractions responsible for dynamic expression lines. Unlike neurotoxin injectables, it works topically at the skin surface level to soften the appearance of existing wrinkles over time.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, mature skin, anti-ageing concerns, expression lines, sensitive skin
What does this do in a formula?
smoothing expression lines, wrinkle reduction, anti-ageing, relaxing facial muscle micro-contractions
Is Pentapeptide-18 safe? Key considerations
Can Pentapeptide-18 cause irritation?
Low RiskSynthetic peptides are generally very well tolerated. No EU CosIng Annex II or III restrictions apply to pentapeptide-18. It is not known to cause sensitisation or contact allergy at typical cosmetic concentrations. No significant adverse effects have been reported in available safety documentation.
Does Pentapeptide-18 increase sun sensitivity?
No RiskPentapeptide-18 does not increase photosensitivity. No special sun protection measures are required based on its presence in a formulation, though daily broad-spectrum SPF is always recommended as part of an anti-ageing routine.
Is Pentapeptide-18 safe during pregnancy?
CautionMANUAL REVIEW: No specific pregnancy safety data for pentapeptide-18 was identified in EWG Skin Deep or MotherToBaby databases during this research. Peptides as a class are generally considered low risk due to their large molecular size limiting systemic absorption, but absence of specific data warrants a cautious stance. Consult a healthcare provider.
How does Pentapeptide-18 work?
Pentapeptide-18, sold under the trade name Leuphasyl, is a synthetic signal peptide composed of five amino acids (tyrosine, alanine, glycine, phenylalanine, and leucine). It works by mimicking the action of enkephalins — natural neurotransmitter-inhibiting peptides — to reduce the intensity of muscle micro-contractions responsible for dynamic expression lines. Unlike neurotoxin injectables, it works topically at the skin surface level to soften the appearance of existing wrinkles over time.
Which products contain Pentapeptide-18?
Shop products that contain Pentapeptide-18
