Researched by Helena DeMaria-Williams
Formula IngredientPeptidePentapeptide-48
INCI: Pentapeptide-48
Pentapeptide-48 is a synthetic peptide composed of five amino acids (threonine, arginine, serine, glutamic acid, and leucine), inspired by royalactin, a protein found in royal jelly. It works by interacting with human growth factor receptors (EGF and TGF-α) to stimulate extracellular matrix production, boost dermal cell proliferation, and activate proteasome activity to clear damaged proteins from skin cells.
Category
Peptide
Irritation Risk
Low
Skin Types
all skin types, ageing skin, uneven skin tone, hyperpigmentation, dull skin, oily, acne-prone
What does this do in a formula?
anti-ageing, firming, smoothing fine lines and wrinkles, evening skin tone, reducing hyperpigmentation, stimulating collagen production, promoting cell renewal, brightening
Is Pentapeptide-48 safe? Key considerations
Can Pentapeptide-48 cause irritation?
Low RiskRated low irritancy (score of 1) by cosmetic ingredient databases. At the recommended formulation concentration of 2–3%, it has been described as non-irritating and non-sensitising. No EU Annex II or III restrictions apply.
Does Pentapeptide-48 increase sun sensitivity?
No RiskPeptides do not increase photosensitivity. No additional sun protection requirements specific to pentapeptide-48.
Is Pentapeptide-48 safe during pregnancy?
SafeSynthetic peptides are generally considered safe during pregnancy. Multiple skincare sources confirm peptides are pregnancy-safe ingredients. As always, check the full product formulation for any co-ingredients (e.g. retinoids or high-concentration acids) that may not be pregnancy-appropriate.
How does Pentapeptide-48 work?
Pentapeptide-48 is a synthetic peptide composed of five amino acids (threonine, arginine, serine, glutamic acid, and leucine), inspired by royalactin, a protein found in royal jelly. It works by interacting with human growth factor receptors (EGF and TGF-α) to stimulate extracellular matrix production, boost dermal cell proliferation, and activate proteasome activity to clear damaged proteins from skin cells.
Individuals with MANUAL REVIEW: No documented contraindications; check full formulation for co-ingredients should review the considerations above before use.
Which products contain Pentapeptide-48?
Shop products that contain Pentapeptide-48
