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By The Skin Formulary Team

Formula IngredientHumectant

Polyglyceryl-6

INCI: Polyglycerin-6

Polyglyceryl-6 (INCI: Polyglycerin-6) is a synthetic polymer composed of six linked glycerol units, also known as hexaglycerin. It functions primarily as a humectant, attracting and retaining water at the skin's surface to improve hydration and create a plumper appearance. It is also used as an emulsifier backbone for polyglyceryl-6 fatty acid esters, and is valued for its mild, PEG-free, vegetable-derived profile.

Category

Humectant

Irritation Risk

Low

Skin Types

all skin types, dry, dehydrated, oily, acne-prone, sensitive, mature

What does this do in a formula?

humectant hydration, water retention, skin plumping, emulsifier support, texture improvement

Important Considerations

Irritation Risk

Low Risk

Polyglyceryl-6 has a 'no penalty' safety profile across all categories according to INCI Beauty. The CIR Expert Panel (2023) concluded it is safe as used in cosmetics. No EU CosIng Annex II or III restrictions apply. True contact allergy is rare.

Sun Sensitivity Risk

No Risk

Polyglyceryl-6 does not increase photosensitivity. No SPF precautions are required due to the presence of this ingredient.

Pregnancy Concerns

Safe

No reproductive or developmental concerns have been identified. Multi-generational rat studies on polyglycerol class ingredients showed no adverse effects on fertility or reproductive outcomes. EWG Skin Deep rates polyglycerin-6 as low hazard for developmental and reproductive toxicity. Topical use at cosmetic concentrations is considered safe during pregnancy.

About This Ingredient

Polyglyceryl-6 (INCI: Polyglycerin-6) is a synthetic polymer composed of six linked glycerol units, also known as hexaglycerin. It functions primarily as a humectant, attracting and retaining water at the skin's surface to improve hydration and create a plumper appearance. It is also used as an emulsifier backbone for polyglyceryl-6 fatty acid esters, and is valued for its mild, PEG-free, vegetable-derived profile.

Individuals with no known contraindications should review the considerations above before use.