Researched by Helena DeMaria-Williams
Formula IngredientPreservative / AntimicrobialPolylysine
INCI: Polylysine
Polylysine (also known as epsilon-polylysine or ε-PL) is a naturally occurring antimicrobial polypeptide produced by fermentation of the bacterium Streptomyces albulus. It consists of a chain of L-lysine amino acids linked by epsilon-amino bonds, giving it a cationic charge that disrupts microbial cell membranes. In cosmetics it is used primarily as a natural preservative and as an anti-acne agent that helps rebalance the skin's microbiome.
Category
Preservative / Antimicrobial
Irritation Risk
Low
Skin Types
oily, acne-prone, combination, sensitive (patch test advised)
What does this do in a formula?
antimicrobial preservation, microbiome rebalancing, anti-acne, broad-spectrum pathogen inhibition
Is Polylysine safe? Key considerations
Can Polylysine cause irritation?
Low RiskPolylysine is a high-molecular-weight biopolymer that is not readily absorbed through intact skin and has a well-established safety record as a food preservative (approved in Japan, the US, and the EU as a food additive). Cosmetic irritation data is limited, but the ingredient is classified by CosIng for use in leave-on formulations without Annex II or III restrictions. Patch testing is advisable for highly sensitive skin.
Does Polylysine increase sun sensitivity?
No RiskPolylysine has no photosensitising properties. No sun protection precautions are required based on its inclusion in a formulation.
Is Polylysine safe during pregnancy?
CautionMANUAL REVIEW: Polylysine has GRAS-equivalent status as a food additive and is not considered systemically absorbed from topical application, suggesting low risk. However, dedicated cosmetic-use pregnancy safety data is limited. Consult a healthcare provider before use during pregnancy if uncertain.
How does Polylysine work?
Polylysine (also known as epsilon-polylysine or ε-PL) is a naturally occurring antimicrobial polypeptide produced by fermentation of the bacterium Streptomyces albulus. It consists of a chain of L-lysine amino acids linked by epsilon-amino bonds, giving it a cationic charge that disrupts microbial cell membranes. In cosmetics it is used primarily as a natural preservative and as an anti-acne agent that helps rebalance the skin's microbiome.
Individuals with known allergy to lysine or polylysine polymers should review the considerations above before use.
Which products contain Polylysine?
Shop products that contain Polylysine
