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Researched by Helena DeMaria-Williams

Formula IngredientAmino Acid

Proline

INCI: Proline

Proline is a non-essential proteinogenic amino acid and one of the major building blocks of dermal collagen. It is a cyclic secondary amine synthesised from glutamic acid, found widely throughout the human body. As a component of the skin's Natural Moisturising Factor (NMF), it helps maintain hydration in the stratum corneum and supports the structural integrity of the skin.

Category

Amino Acid

Irritation Risk

Low

Skin Types

all skin types, ageing skin, dry skin, dehydrated skin

What does this do in a formula?

collagen production support, hydration, skin conditioning, anti-ageing, improved skin elasticity, skin repair and regeneration

Is Proline safe? Key considerations

Can Proline cause irritation?

Low Risk

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that proline and other alpha amino acids are safe as used in cosmetics. Dermal studies indicate it is not a skin irritant or sensitiser. No EU CosIng Annex II or III restrictions apply.

Does Proline increase sun sensitivity?

No Risk

Proline does not increase photosensitivity. No special sun protection measures are required when using proline-containing products.

Is Proline safe during pregnancy?

Caution

Proline is a naturally occurring amino acid in the body and is generally considered low risk. However, WebMD notes there is not enough reliable information to confirm safety of topical proline during pregnancy. Consult a healthcare provider. Amounts found naturally in foods are considered safe.

How does Proline work?

Proline is a non-essential proteinogenic amino acid and one of the major building blocks of dermal collagen. It is a cyclic secondary amine synthesised from glutamic acid, found widely throughout the human body. As a component of the skin's Natural Moisturising Factor (NMF), it helps maintain hydration in the stratum corneum and supports the structural integrity of the skin.