Researched by Helena DeMaria-Williams
Formula IngredientAntioxidantINCI: Ubiquinone
Ubiquinone (Coenzyme Q10, CoQ10) is a fat-soluble organic compound naturally present in every human cell, where it plays a central role in mitochondrial energy production. When applied topically, it penetrates into the upper layers of the skin and acts as a potent antioxidant, neutralising free radicals generated by UV exposure and environmental aggressors. Skin levels of ubiquinone decline with age, making topical supplementation a useful strategy for supporting the skin's natural antioxidant defences.
Category
Antioxidant
Irritation Risk
Low
Skin Types
all skin types, mature skin, anti-ageing concerns, environmentally stressed skin, sensitive skin
antioxidant protection, anti-ageing, reduces wrinkle depth, supports cellular energy metabolism, reduces oxidative stress, brightening
CoQ10 is well tolerated across skin types. Studies show its irritancy potential is comparable to vehicle controls even in sensitive-skin individuals, with no cytotoxicity observed in keratinocytes at concentrations far exceeding typical cosmetic use. No EU CosIng Annex II or III restrictions apply.
Ubiquinone does not increase photosensitivity. It is an antioxidant that helps counteract UV-induced oxidative damage, and no SPF precautions are required based on its presence in a formulation.
Animal studies in rats, rabbits, and mice found no statistically significant adverse effects on fetal development at tested dosages, and no effects on fertility or reproductive performance. Human topical data is limited, but the ingredient is considered low risk. No concerns are flagged by EWG or LactMed for cosmetic use.
Ubiquinone (Coenzyme Q10, CoQ10) is a fat-soluble organic compound naturally present in every human cell, where it plays a central role in mitochondrial energy production. When applied topically, it penetrates into the upper layers of the skin and acts as a potent antioxidant, neutralising free radicals generated by UV exposure and environmental aggressors. Skin levels of ubiquinone decline with age, making topical supplementation a useful strategy for supporting the skin's natural antioxidant defences.
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