What are the benefits of Diisopropyl Sebacate for skin?

skin softening, non-greasy emolliency, enhanced spreadability, solubilising UV filters, lightweight texture, rapid absorption

What concentration of Diisopropyl Sebacate is effective?

Typical effective concentrations of Diisopropyl Sebacate are 1–10% in the oil phase of formulations, at 5% can boost SPF by ~21%, at 10% by ~33% in sunscreen formulations.

What skin types is Diisopropyl Sebacate suitable for?

Diisopropyl Sebacate is suitable for oily, combination, normal, dry, sensitive.

Diisopropyl Sebacate — Skincare Ingredient Guide

Q: Can Diisopropyl Sebacate cause skin irritation?

Diisopropyl Sebacate has a low irritation risk. Considered minimally irritating based on CIR Expert Panel data — only mild eye irritation was observed in animal studies at high concentrations. Note: one study found diisopropyl sebacate can facilitate skin sensitisation to certain haptens (FITC) via TRPA1 receptor activation, though this is not considered a standard sensitisation concern at typical cosmetic use levels. No EU CosIng Annex II (banned) or Annex III (restricted) classifications apply.

Q: Is Diisopropyl Sebacate safe to use during pregnancy?

Diisopropyl Sebacate is rated "caution" for pregnancy use. No evidence links topical diisopropyl sebacate to developmental or hormonal concerns, and ECHA registration data does not classify it for reproductive toxicity. It is generally viewed as low risk during pregnancy for topical use. However, as with all cosmetic ingredients, consultation with a healthcare provider is recommended.

Q: Does Diisopropyl Sebacate increase sun sensitivity?

Diisopropyl Sebacate has a no sun sensitivity risk. Diisopropyl sebacate does not absorb UV light and does not increase photosensitivity. It is in fact commonly used as a solvent to enhance the performance and SPF of sunscreen formulations.

Diisopropyl Sebacate

INCI: Diisopropyl Sebacate

Diisopropyl sebacate is a synthetic diester of isopropyl alcohol and sebacic acid (a dicarboxylic acid derived from castor oil). It is a clear, colourless, practically odourless lightweight liquid that functions as an emollient, solvent, and plasticiser in cosmetic formulations. It works by filling microscopic gaps between skin cells to improve softness, and dissolves oil-soluble actives such as UV filters and fragrances.

Is Diisopropyl Sebacate safe? Key considerations

Can Diisopropyl Sebacate cause irritation?

Low Risk

Considered minimally irritating based on CIR Expert Panel data — only mild eye irritation was observed in animal studies at high concentrations. Note: one study found diisopropyl sebacate can facilitate skin sensitisation to certain haptens (FITC) via TRPA1 receptor activation, though this is not considered a standard sensitisation concern at typical cosmetic use levels. No EU CosIng Annex II (banned) or Annex III (restricted) classifications apply.

Does Diisopropyl Sebacate increase sun sensitivity?

No Risk

Diisopropyl sebacate does not absorb UV light and does not increase photosensitivity. It is in fact commonly used as a solvent to enhance the performance and SPF of sunscreen formulations.

Is Diisopropyl Sebacate safe during pregnancy?

Caution

No evidence links topical diisopropyl sebacate to developmental or hormonal concerns, and ECHA registration data does not classify it for reproductive toxicity. It is generally viewed as low risk during pregnancy for topical use. However, as with all cosmetic ingredients, consultation with a healthcare provider is recommended.

How does Diisopropyl Sebacate work?

Individuals with known allergy to sebacate esters should review the considerations above before use.

Diisopropyl Sebacate

What does this do in a formula?

Is Diisopropyl Sebacate safe? Key considerations

Can Diisopropyl Sebacate cause irritation?

Does Diisopropyl Sebacate increase sun sensitivity?

Is Diisopropyl Sebacate safe during pregnancy?

How does Diisopropyl Sebacate work?

Which products contain Diisopropyl Sebacate?

Advanced 0.2% Retinal Serum