Researched by Helena DeMaria-Williams
Formula IngredientCell-Communicating PeptideTripeptide-1
INCI: Tripeptide-1
Tripeptide-1 (INCI: Tripeptide-1) is a synthetic signal peptide composed of three amino acids — glycine, histidine, and lysine (GHK). It mimics a collagen breakdown fragment that signals the skin to produce new collagen, elastin, and other extracellular matrix proteins. It also acts as a natural copper-binding carrier, forming GHK-Cu when paired with copper ions, which amplifies its tissue-repair and anti-ageing effects.
Category
Cell-Communicating Peptide
Irritation Risk
Low
Skin Types
all skin types, mature skin, anti-ageing concerns, acne-prone, hyperpigmentation, photodamaged skin
What does this do in a formula?
collagen synthesis stimulation, elastin production, wrinkle reduction, skin firmness, wound healing, hyperpigmentation reduction, photodamage repair, skin barrier support, acne scar healing
Is Tripeptide-1 safe? Key considerations
Can Tripeptide-1 cause irritation?
Low RiskTripeptide-1 is well tolerated across skin types with no reported significant irritation in published literature or cosmetic safety assessments. Decades of use in cosmetic products have not produced adverse effects. No EU CosIng Annex II or III restrictions apply.
Does Tripeptide-1 increase sun sensitivity?
No RiskTripeptide-1 does not increase photosensitivity. It has no exfoliating or photosensitising mechanism. No special sun protection precautions are required due to its presence in a formulation.
Is Tripeptide-1 safe during pregnancy?
CautionThere is insufficient clinical data on the use of synthetic peptides including Tripeptide-1 during pregnancy. While no specific safety concerns have been identified, peptides are generally understudied in pregnancy contexts. As a precaution, consult a healthcare provider before using peptide-heavy formulations during pregnancy.
How does Tripeptide-1 work?
Tripeptide-1 (INCI: Tripeptide-1) is a synthetic signal peptide composed of three amino acids — glycine, histidine, and lysine (GHK). It mimics a collagen breakdown fragment that signals the skin to produce new collagen, elastin, and other extracellular matrix proteins. It also acts as a natural copper-binding carrier, forming GHK-Cu when paired with copper ions, which amplifies its tissue-repair and anti-ageing effects.
Which products contain Tripeptide-1?
Shop products that contain Tripeptide-1
Exosome Glow Serum
Caffeine Eye Cream
Hyaluronic Acid Serum
Hyaluronic Acid Serum
Supersize Hyaluronic Acid Serum
Tripeptide Plumping Lip Balm
Collagen Peptide Serum
Retinol Serum
Multi-Peptide + Copper Peptides 1% Serum
Matrixyl 10% + HA
Multi-Peptide + HA Serum
